Ingredient Moderate Evidence

Phosphatidylserine

Phospholipid studied for memory and age-related cognitive decline.

Reviewed for medical accuracy · Health Editorial Team
Updated May 2026

Quick answer: This ingredient has moderate evidence — some solid clinical support, though results aren't fully consistent across studies. Phospholipid studied for memory and age-related cognitive decline.

What Is Phosphatidylserine?

Phosphatidylserine is most commonly studied and used for memory & focus. Phospholipid studied for memory and age-related cognitive decline. The strength of evidence behind it is currently classified as moderate — this ingredient has moderate evidence — some solid clinical support, though results aren't fully consistent across studies.

Which of Our Products Include Phosphatidylserine?

Here's where Phosphatidylserine shows up in our current formulas:

Synaptril

Memory & Focus Formula View Product →

Works Well Combined With

In the Memory & Focus category, Phosphatidylserine is often formulated alongside other ingredients that target the same goal through different mechanisms — which is why you'll frequently see it in a blend rather than sold alone:

  • Bacopa Monnieri
  • Omega-3 (DHA)
  • Ginkgo Biloba
  • Lion's Mane Mushroom
  • Alpha-GPC

Combining ingredients with different, complementary mechanisms is generally more useful than taking several ingredients that all do the same thing — it's worth checking a product's full ingredient list rather than judging it on one "hero" ingredient alone.

A Quick Note on Safety

As with any supplement ingredient, individual response varies, and it's worth checking with a healthcare provider before starting Phosphatidylserine if you're pregnant, nursing, taking medication, or managing a health condition. For a full breakdown of dosage and side effects, see the related health goal guide below.

Frequently Asked Questions

Is Phosphatidylserine safe to take daily?

At studied doses, most people tolerate it well, though it's always worth checking with a healthcare provider, especially if combined with other supplements or medication.

How is the evidence level determined?

We classify evidence as Strong, Moderate, or Limited based on the quantity, size, and consistency of clinical research specifically studying this ingredient for this use. See our Editorial Policy for details.

Can I take Phosphatidylserine on its own instead of a blended formula?

Yes — standalone versions are usually available. A blend simply combines it with complementary ingredients for convenience and broader coverage of the same health goal.